邢唷> 欹亖 嶽bjbj堤堤 i爪爪4RY{ { { { { $ P tc! SB!!!!!"6#$2#鯝鳤鳤鳤鳤鳤鳤驞旼鳤{ F#""F#J#鳤+{ { !! B+++N#6{ !{ !鯝+F#鯝++r={ { F@溃嶨寗 'l?(b@#B0SB@({I+{IPF@+{ F@F#F#F# A:   BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.NAME Yimin ZouPOSITION TITLE ProfessoreRA COMMONS USER NAME (credential, e.g., agency login) YIMINZOUEDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)INSTITUTION AND locationsDEGREE (if applicable)MM/YYFIELD OF STUDYDept of Genetics, Fudan University, ShanghaiB.S.1984-1988GeneticsUniversity of California, Davis and San DiegoPh. D.1989-1995Biochemistry and Molecular Biology With Kenneth R. ChienUniversity of California, San DiegoPostdoctoral Fellowship1995-1996Developmental Biology with Kenneth R. ChienUniversity of California, San FranciscoPostdoctoral Fellowship1996-2000Developmental Neuroscience with Marc Tessier-Lavigne A. Personal Statement My lab studies molecular and cellular mechanisms of axon guidance, functional neural circuit assembly, maintenance and stability of neuronal networks and axon regeneration following spinal cord injury. We identify molecular guidance cues that provide directional information for axon wiring in vivo as well as signal transduction pathways and cell biological mechanisms underlying growth cone turning. We also study how specific synaptic connection patterns emerge from the interplay of molecular guidance system and neural activity to give rise to functional circuits. We study how the central nervous system responds to traumatic injury and develop therapeutic approaches to promote axonal and neuronal survival to combat degenerative disorders and improve axon regeneration and functional recovery following spinal cord injury. These projects are coherently organized in the lab, providing broad training opportunities for postdoctoral fellows and also chances to collaborate with other lab members. I worked with March Tessier-Lavigne as a postdoctoral fellow in the area of axon guidance and neural development and have established my own lab focusing on axon guidance at the University of Chicago in 2000, where I received tenure. I moved to UCSD Neurobiology in 2006 and continue to expand my research program to include functional organization of neural circuits, neurodegeneration and spinal cord injury. I am currently a full professor in the Neurobiology Section. UCSD is a highly cohesive and interactive environment, where frequent scientific discussions and collaborations take place. We have a monthly Neurodinner (which has over 30 years of history), where ongoing projects are presented by postdocs and students to the rest of the Neurobiology Section; a quarterly Neurodevelopment meeting and an annual Neural Regeneration meeting, where labs from UCSD, Salk Institute and Scripps Institute present unpublished work; weekly Neurolunch among Neurobiology faculty with research chalk talks; and many other occasions. My lab currently has five postdocs, one Ph.D. students, and two technicians. Two more postdocs are arriving in the next six months. My lab has weekly lab meetings and biweekly journal clubs. I encourage postdoc fellows and grad students to attend meetings at least once a year, such as Gordon Conference, Cold Spring Harbor, Keystone, Society for Neuroscience, Wnt Signaling Meeting, etc. I encourage trainees to take initiatives to design experiments, interpret results and write manuscripts, although I also provide guidance and suggestions along the way. B. Positions and Honors Positions and Employment 12/1996-10/2000 Postdoctoral Fellowship, University of California, San Francisco. 11/2000-04/2006 Assistant Professor, Dept of Neurobiology, Pharmacology and Physiology. The University of Chicago. 05/2006-06/2006 Associate Professor (with tenure), Dept of Neurobiology, Pharmacology and Physiology. The University of Chicago. 07/2006-06/2011 Associate Professor, Neurobiology Section, Biological Sciences Division. University of California, San Diego 07/2011-Present Full Professor, Neurobiology Section, Biological Sciences Division. University of California, San Diego Other Experience and Professional Memberships Faculty Search Committee, Dept of Neurobiology, Pharmacology and Physiology, U Chicago Graduate Admission Committees for Developmental Biology and Neurobiology, U Chicago Organizing Committee, Chicago Signal Transduction Symposium Curriculum Committee, Committee on Developmental Biology, the University of Chicago International Graduate Student Admission Committee, Molecular Biosesciences, U Chicago Graduate Student Travel Award Committee, Neurobiology, U Chicago Neuroscience Task Force, Biological Science Division, U Chicago Divisional Search Committee for Director of Center for Stem Cell Research and Regenerative Medicine, U Chicago UCSD Neuroscience Program Recruitment Coordinator (co-chair, 2006-present) UCSD/Salk Biology Program Retreat Planning Committee (chair, 2008-2011) UCSD Kamen Prize Committee for Best Chemistry and Biochemistry Ph.D. Thesis (Chair, 2010-2012) NIH Training Grant Co-Director: Developmental Biology of Neural Disease (2009-present) Ad Hoc Member of NIH and DoD Study Sections NIH NDPR Study Section Regular Member (July 2011- June 2017) UCSD Academic Senate Faculty Welfare Committee (2011-2012) Editorial Board: Developmental Neurobiology, Neural Regeneration Research and Neuroscience Bulletin (Associate Editor) Honors 1989-1993 CUSBEA Fellowship 1993-1995 Institutional Predoctoral NRSA, NIH 1995-1996 Institutional Postdoctoral NRSA, NIH 1996-1998 Individual Postdoctoral NRSA, NIH Postdoctoral Fellowship from the Spinal Cord Research Foundation 2002-2005 Schweppe Foundation Career Development Award March of Dimes Basil O扖onnor Starting Scholar Research Award Alfred P. Sloan Research Fellow Award W. M. Keck Foundation Research Achievement Award (Semi-finalist in Keck Young Scholar Competition) C. Selected Peer-reviewed Publications Most relevant to the current application 1. Anna I. Lyuksyutova, Chin-Chun Lu, Nancy Milanesio, Leslie A. King, Nini Guo, Yanshu Wang, Jeremy Nathans, Marc Tessier-Lavigne and Yimin Zou*. Anterior-posterior guidance of commissural axons by Wnt-Frizzled signaling. Science. 2003. 302, 1984-1988. (PMC Journal-In process). (evalsuated by Faculty of 1000 Biology). 2. Yaobo Liu, Jun Shi, Chin-Chun Lu, Zheng-Bei Wang, Xuejun Song and Yimin Zou*. Anterior-posterior guidance of corticospinal tract axons by conserved repulsive Wnt-Ryk interaction. Nature Neuroscience. 2005. 8(9):1151-9. (PMC Journal-In process). (evalsuated by Faculty of 1000 Biology) 3. Adam Schmitt, Jun Shi, Alex Wolf, Chin-Chun Lu, Leslie A. King and Yimin Zou*. Wnt-Ryk signaling mediates medial-lateral retinotectal topographic mapping. Nature. 2006. 439(7072):31-7. (PMC Journal-In process). (evalsuated by Faculty of 1000 Biology) 4. Alex M. Wolf , Anna I. Lyuksyutova, Ali G. Fenstermaker, Beth Shafer, Charles G. Lo and Yimin Zou*. PI3K-atypical PKC signaling is required for Wnt attraction and anterior-posterior axon guidance. Journal of Neuroscience. 2008. 28(13):3456-3467. (PMC Journal-In process). 5. Yaobo Liu, Xiaofei Wang, Chin-Chun Lu, Rachel Kermen, Oswald Steward*, Xiao-Ming Xu* and Yimin Zou*. Repulsive Wnt signaling inhibits axon regeneration following central nervous system injury. Journal of Neuroscience. 2008. 28(33):8376-8382. (PMC Journal-In process). (evalsuated by Faculty of 1000 Biology) 6. Elizabeth K. Davis, Yimin Zou and Anirvan Ghosh*. Wnts acting through canonical and non-canonical pathways exert opposite effects on hippocampal synapse formation. Neural Development. November 5, 2008. 3:32. Doi:10.1186/1749-8104-3-32. PMC2596118. 7. Liseth Parra and Yimin Zou*. Sonic hedgehog induces response of spinal cord commissural axons to Semaphorin repulsion during midline crossing. Nature Neuroscience. Nature Neuroscience. 2010 Jan;13(1):29-35. (evalsuated by Faculty of 1000 Biology) 8. Ali G. Fenstermaker, Asheeta Prasad, Ahmad Bechara, Youri Adolfs, Fadal Tissir, Andre Goffinet, Yimin Zou, Y*, R. Jeroen Pasterkamp*. Wnt-Planar Cell Polarity signaling controls the anterior-posterior organization of monoaminergic axons in the brainstem. Journal of Neuroscience. 2010. 30(47):16053-16064. 9. Beth Shafer, Charles Lo, Keisuke Onishi and Yimin Zou*.  HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed/21316586" Vangl2 Promotes Wnt/Planar Cell Polarity-like Signaling by Antagonizing Dvl1-Mediated Feedback Inhibition in Growth Cone Guidance. Developmental Cell. 2011 Feb 15;20(2):177-91. 10. Kristen N. Fantetti, Yimin Zou and Donna M. Fekete*. Wnts and Wnt inhibitors do not influence axon outgrowth from chicken statoacoustic ganglion neurons. Hearing Research (2011). doi:10.1016/j.heares.2011.04.005. 11. Delphine Delaunay and Yimin Zou*. Vangl2 is required cell-autonomously for maintaining neural progenitor pools by inhibiting asymmetric cell divisions in the developing neocortex. Journal of Neuroscience. In review. 12. Alisha Richman and Yimin Zou*. Laterally moving balance point of two opposing mapping gradients specifies topographic positions in retinotectal targeting. Nature Neuroscience. In review. * Corresponding Author Additional recent publications of importance to the field (in chronological order) 1. Hang Chen, Anil Bagri, Joel A. Zupicich, Yimin Zou, Esther Stoeckli, Samuel J. Pleasure, Daniel H. Lowenstein, William C. Skarnes, Alain Ch閐otal, and Marc Tessier-Lavigne*. Neuropilin-2 regulates the development of select cranial and sensory nerves and hippocampal mossy fiber projections. Neuron. 2000. 25(1): 43-56. (PMC Journal-In process). 2. Yimin Zou, Esther Stoeckli, Hang Chen, and Marc Tessier-Lavigne*. Squeezing axons out of the gray matter: A role for slit and semaphorin proteins from midline and ventral spinal cord. Cell. 2000. 102, 363-375. (PMC Journal-In process). 3. Elke Stein, Yimin Zou, Mu-ming Poo, and Marc Tessier-Lavigne*. Binding of DCC by Netrin-1to mediate axon guidance independent of adenosine A2B receptor activation. Science. 2001. 291, 1976-1982. (PMC Journal-In process). 4. Yimin Zou*, Florian Engert and Huizhong Tao. Meeting review on 搕he Assembly of Neural Circuits. Neuron. 2004. 43:1-5. (PMC Journal-In process). 5. Yimin Zou*. Wnt signaling in axon guidance. Trends in Neurosciences. 2004. 27(9): 528-532. (PMC Journal-In process). 6. Lee Fradkin, Gian Garriga , Patricia C. Salinas, John Thomas, Xiang Yu and Yimin Zou*. Wnt signaling in neural circuit development. Journal of Neuroscience. November 9, 2005. 25(45):10376-10378. (PMC Journal-In process). 7. Yimin Zou*. Navigating the anterior-posterior axis with Wnts. Neuron. 2006 Mar 16;49(6):787-9. (PMC Journal-In process). 8. Yimin Zou* and Anna I. Lyuksyutova. Morphogens in axon guidance. Current Opinions in Neurobiology. 2007 Jan 29. (PMC Journal-In process). 9. Patricia Salina* and Yimin Zou*. Wnt signaling and neuronal circuit assembly. Annu Rev Neurosci. 2008 Jul 21;31:339-358. (PMC Journal-In process). 11. Esther Stoeckli* and Yimin Zou*. How are neurons wired to form functional and plastic circuits? Meeting on Axon Guidance, Synaptogenesis and Neural Plasticity (Cold Spring Harbor Laboratories). EMBO J. 2009 Apr; 10(4):326-30. PMC2672895. 12. Yimin Zou*. Axons find their way in the snow. Meeting report on Keystone Symposium on 揂xonal Connections. Development. 2009 136:2135-2139 (PMC Journal-In process). 13. Barry Dickson* and Yimin Zou*. Navigating intermediate targets: the nervous system midline. Chapter in Cold Spring Harbor Perspectives in Biology 揘euronal Guidance. 2010. *Corresponding Author D. Research Support Ongoing Research Support 1. Packard ALS Center at Johns Hopkins grant 10/01/2010-09/31/2012 揗otor Axon Degeneration and ALS The major goal is to understand the signaling mechanisms leading to the survival of motor neuron axons and cell bodies in normal development and neurodegenerative disorders. 2. R01 NS047484 12/01/2003 - 2/28/2014 NIH/NINDS 揅haracterizing Wnt signaling pathways in axon guidance The major goal of this project is to understand the molecular and cellular mechanisms of axon guidance during nervous system development. 3. Wings for Life Foundation on Spinal Cord Injury 7/01/2011-6/30/2012 揥nt signaling in corticospinal tract axon regeneration The major goal is to develop therapeutic tools to block axon retraction and promote regeneration. Completed Research Support 1. R01 NS046357 10/1/06-12/31/08 NIH/NINDS 揝ignaling Pathways in Axon Pathfinding The goal was to understand how Semaphorins and Slit signaling pathways interact with each other in mediating midline repulsion of commissural axons. 2. NARSAD 9/15/07-9/14/09 揟he Function and Mechanism of DISC1 in Mediating Axon Growth and Guidance The goal was to explore the connection of the Wnt signaling pathway to DISC1, a gene implicated in schizophrenia. 3. WFL-US-018/08 9/1/08-9/1/09 Wings for Life 揗otor neurons, stem cells, Wnt/PCP pathway, asymmetric division The goal was to study how neurons are born and differentiated from progenitor cells. 4. RR08-234 1/1/09-12/31/09 Roman Reed Foundation 揥nt signaling in central nervous system regeneration The goal was to Making monoclonal antibodies to Ryk and making a Ryk conditional KO mice. 5. RR10-270 1/1/10-12/31/10 Roman Reed Foundation 揥nt signaling in sensory axon injury and regeneration The goal was to explore the role of Wnt signaling in proprioceptive axon regeneration. 6. Kavli Institute Award 7/01/2010-6/30/2011 揇evelopment of the perforant pathway The major goal is to understand the molecular guidance mechanisms that control the development of the connections from the entorhinal cortex to the hippocampus, which is important for spatial perception and learning and memory. Seminars University of Western Ontario; Loyola University (Medical School); University of Wisconsin, Madison; Loyola University (Department of Biology); Johns Hopkins University Medical School; Rush University Medical School; Luther College; University of Navada; Ernest Gallo Clinic and Research Center UC, San Francisco; Harvard Medical School Children抯 Hospital; Biogen (2005&2008); University College London; University of Zurich; Northwestern University; Cornell University Weill Medical College; University of Illinois, Urbana-Champaign; University of British Columbia; Yale University; University of Miami; Zhejiang University Biology, China; UNC Chapel Hill; Riken BRI, Japan; King抯 College London; University of Sheffield, England; University of Louvain, Belgium (2007); UC, Santa Cruz; Penn State; University of Virginia; Mayo Clinic; SUNY Stony Brook; Institute of Biophysics, Chinese Academy of Sciences; Friedrich Miescher Institut, Swizterland; Biogen, Idec; Kyoto University, Japan; Zhejiang University Medical School, China; Indiana University; Montreal Neurological Institute McGill University, Canada; Mount Sinai School of Medicine; University of Leuven, Belgium (2009); Max Planck Institute of Munich, Germany; Institute of Neurosciences, Chinese Academy of Sciences, Shanghai, China (2006&2009); The University of Pennsylvania; University Medical Center Utrecht, Utrecht, the Netherlands; NIH/NHGRI; Hangzhou Normal University, China; UCLA; University of Leiden, the Netherlands; The Karolinska Institute; Institut of Vision, Paris France; Queensland Brain Institute (QBI), University of Queensland, Australia; Jinan University, China; Suzhou University; Drexel University, Philadelphia; UT Southwestern, Dallas; Duke; Cincinnati Children抯 Hospital, Ohio; University of Ottawa, Canada; Helmholtz Center, Munich Germany; University of Bourdeux, France. Meeting talks Midwest Developmental Biology Meeting. Columbia, Missouri. 2001. Society for Neuroscience (the Chicago Chapter) Symposium on Neurodevelopment and Disease. Chicago. 2002. Midwest Neurobiology Meeting in Ames, IA. 2003. Society for Developmental Biology 62nd Annual Meeting in Boston, Symposium 1, From Neuron to Brain. 2003. EMBO Workshop on : The Assembly of Neural Circuits, Varenna, Italy. 2003. Friedrich Miescher Institut Conference on: Formation and Function of Neuronal Circuits, Ascona, Switzerland. 2003. The Robert Packard Center for ALS Research 3rd Annual Symposium, Baltimore, Maryland. 2004. The 3rd Symposium on Neuroscience of Young Scholars Worldwide. Guangzhou, China. 2004 Symposium on Development and Plasticity of Neural Circuits. Fudan University, Shanghai, China. 2004. Keystone Symposium on Axonal Connections: Molecular Cues for Development and Regeneration. Breckenridge, CO. 2005. 11th annual Kentucky Spinal Cord and Head Injury Research Trust Symposium. Louisville, Kentucky. 2005. Axon Guidance and Regeneration Workshop by Foundation des Treilles. Les Treilles, France. 2005. Banbury Center Meeting on Stem Cells and Axonal Regeneration: Strategies for the Treatment of ALS. Cold Spring Harbor. 2005. The Robert Packard Center for ALS Research 4th Annual Symposium, Baltimore, Maryland. 2005. Society for Neuroscience 揗inisymposium on Wnt Signaling in Neural Circuit Development (Chair). Washington, DC. 2005. Midwest Student Biomedical Research Forum (Keynote Speaker). Omaha, Nebraska. February 2006. The Robert Packard Center for ALS Research 5th Annual Symposium, Baltimore, Maryland. April 2006. Symposium on Axon Guidance and Regeneration at Institute of Life Sciences. Beijing, China, June 2006. Symposium on Axon Guidance and Regeneration at Chinese Academy of Sciences. Shanghai, China, June 2006. 16th Biennial Meeting of the International Society for Developmental Neuroscience (ISDN). 揂xon pathfinding mechanisms Session. Banff Centre, Alberta, Canada, August 2006. Winter Conferences on Brain Research, Snowmass. January 2007. Symposium at the Association for Research in Otolaryngology. Denver. February 2007. The Robert Packard Center for ALS Research 6th Annual Symposium, Baltimore, Maryland. April 2007. Wnt Signaling Meeting. San Diego. June 2007. Chinese Biological Investigators (Ray Wu) Society Symposium. Beijing China. July 2007. The Robert Packard Center for ALS Research 7th Annual Symposium, Baltimore, Maryland. April 2008. Wings for Life Functional Recovery Following Spinal Cord Injury. at Salzburg, Austria. April 28-May 4, 2008. 6th FENS Forum of European Neuroscience: Genetic Control of Neural Circuit Development. Geneva Switzerland, July 2008. Gordon Research Conference on Neural Development. Newport, Rhode Island. August 2008. Society for Neuroscience 揝ymposium on Genetic determinants specifying neuronal connections (Chair). Washington, DC. November 2008. Keystone Symposium on Axonal Connections: Molecular Cues for Development and Regeneration. Keystone, Colorado. February 2009. Roman Reed Research Meeting. Irvine, CA. March, 2009. Robert Packard Center for ALS Research 8th Annual Symposium. Baltimore, Maryland. April 2009. Symposium on Neural Development and Plasticity at Peking University (Chair). Beijing, China, November 2009. Symposium on Neural Development and Plasticity at Chinese Society for Neuroscience Biannual Meeting (Chair). Guangzhou, China. November 2009. Symposium on Neural Development and Plasticity at Hong Kong University of Science and Technology. Hong Kong, China. November 2009. Wnt/PCP Meeting. Alba, Italy. May 2010. Gordon Conference on Neural Development. Newport, Rhode Island. August 2010. The Robert Packard Center for ALS Research 10th Annual Symposium, Baltimore, Maryland. March, 2011. Wnt Meeting. Los Angeles, CA. June-July 2011. 8th IBRO World Congress of Neurosciences (Symposium Organizer: Signaling and cell biological mechanisms of growth cone guidance). Florence Italy July 2011. Chinese Society of Neuroscience (Symposium Organizer and speaker). Zhengzhou, China. July 2011. Neural Circuit Development Symposium. Hangzhou Normal University. Hangzhou, China. August 2011. Japanese Society for Neuorscience (Symposium Organizer and speaker). Yokohama, Japan. September 2011. Symposium on Neural Circuits at Peking University. Peking, China. October 2011. Cold Spring Harbor Asia Meeting on Neural Circuits (Organizer and speaker). Suzhou China. October 2011. Symposium on Neural Circuits at Zhejiang University. Hangzhou, China. October 2011. Society for Neuroscience Annual Meeting Symposium on Planar Cell Polarity (PCP): the many roles of PCP genes in shaping the nervous system. Washington, DC. November 2011. The Robert Packard Center for ALS Research 11th Annual Symposium, Baltimore, Maryland. March 2012. Wings for Life Foundation Research Symposium. Salzburg, Austria. May 2012. 8th FENS Forum of Neuroscience Symposium on 揚lanar cell polarity (PCP) shapes the nervous system. Barcelona, Spain. July 2012.     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